Technology Process of 10-(tert-butyldiphenylsiloxy)-1-(trimethylsilyl)deca-1,8-diyne
There total 1 articles about 10-(tert-butyldiphenylsiloxy)-1-(trimethylsilyl)deca-1,8-diyne which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl(diphenyl)(2-propynyloxy)silane;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
7-iodo-1-(trimethylsilyl)-1-heptyne;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 14h;
DOI:10.1016/j.tet.2005.08.088
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
2: 79 percent / CuI; diisopropylamine / Pd(PPh3)2Cl2 / tetrahydrofuran / 24 h / 20 °C
3: triethylamine / tetrahydrofuran / -78 °C
With
copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran;
DOI:10.1016/j.tet.2005.08.088
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
2: 79 percent / CuI; diisopropylamine / Pd(PPh3)2Cl2 / tetrahydrofuran / 24 h / 20 °C
3: triethylamine / tetrahydrofuran / -78 °C
4: m-chloroperbenzoic acid / CH2Cl2 / 0 °C
With
copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2005.08.088
