10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol

Base Information

Chemical Name:10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol
CAS No.:1257204-09-3
Molecular Formula:C₅₁H₆₅N₃O₁₇
Molecular Weight:992.087
Hs Code.:

Synonyms:10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol

Suppliers and Price of 10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol

There total 3 articles about 10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23744-06-1
N-morpholin-4-yl-succinamic acid

: 114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0
Docetaxel

: 1257204-09-3
10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 - 30 ℃; for 6h; Inert atmosphere;

Reference yield:

: 1257204-11-7
10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-piperidin-1-yl)succinamidoyl]taxol

: 1257204-09-3
10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol

Guidance literature:: Multi-step reaction with 2 steps

1: human plasma / 6 h / 37 °C / Enzymatic reaction

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 25 - 30 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

Reference yield:

: 960155-98-0
docetaxel 2'-succinic ester

: 1257204-09-3
10-deacetyl-N-debenzoyl-N-(tert-butyloxycarbonyl)-2'-[(N-morphoIin-4-yl)succinamidoyl]taxol

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 6 h / 25 - 30 °C / Inert atmosphere

2: human plasma / 6 h / 37 °C / Enzymatic reaction

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 25 - 30 °C / Inert atmosphere

With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;