1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:127728-29-4
Molecular Formula:C₁₈H₁₉N₅O₄
Molecular Weight:369.38
Hs Code.:

Synonyms:1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

There total 1 articles about 1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 536-74-3
phenylacetylene

: 127728-29-4
1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol; In water; tert-butyl alcohol; at 20 ℃; for 0.5h; Solvent; Reagent/catalyst; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2021.132252

Reference yield:

: 127728-29-4
1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: 62420-37-5
(p-chlorophenyl) di(1,2,4-triazolido)phosphate

: C₂₆H₂₄ClN₈O₅P

Guidance literature:: With pyridine; at 20 ℃; for 1h;
DOI:10.1080/15257770.2019.1594282

Reference yield:

: 127728-29-4
1-((2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: C₁₈H₂₀N₅O₇⁽³²⁾P

Guidance literature:: With hydrogenchloride; recombinant Ureaplasma parvum Q₉PPP₅ thymidine kinase; ATP; 2-amino-2-hydroxymethyl-1,3-propanediol; magnesium chloride; D,L-dithiothreitol; bovine serum albumin; In water; dimethyl sulfoxide; at 37 - 95 ℃; for 0.366667h; pH=7.6; Reagent/catalyst; Time; Kinetics; Enzymatic reaction;
DOI:10.1016/j.bmc.2010.03.023