4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate

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Chemical Name:4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate
CAS No.:1265882-27-6
Molecular Formula:C₃₁H₃₈N₂O₇
Molecular Weight:550.652
Hs Code.:

Synonyms:4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate

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Chemical Property of 4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate

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Technology Process of 4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate

There total 2 articles about 4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 8-(4-(hydroxymethyl)phenyl)-2-morpholino-4H-chromen-4-one

: 1265882-27-6
4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/jm300881a

Reference yield:

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 1265882-27-6
4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; potassium carbonate / ethanol; acetonitrile / Reflux; Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

With dmap; palladium diacetate; potassium carbonate; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1021/jm300881a