4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate

Base Information

Chemical Name:4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate
CAS No.:1395832-67-3
Molecular Formula:C₂₆H₃₀N₂O₅
Molecular Weight:450.535
Hs Code.:

Synonyms:4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate

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Chemical Property of 4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate

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Technology Process of 4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate

There total 4 articles about 4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1265882-27-6
4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate

: 1395832-67-3
4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate

Guidance literature:: With toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 65h;
DOI:10.1021/jm300881a

Reference yield:

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 1395832-67-3
4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; potassium carbonate / ethanol; acetonitrile / Reflux; Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

3: toluene-4-sulfonic acid / acetonitrile / 65 h / 20 °C

With dmap; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1021/jm300881a

Reference yield:

: 351002-11-4
trifluoromethanesulfonic acid 2-(morpholin-4-yl)-4-oxo-4H-chromen-8-yl ester

: 1395832-67-3
4-(2-morpholino-4-oxo-4H-chromen-8-yl)benzyl 2-amino-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; potassium carbonate / ethanol; acetonitrile / Reflux; Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

3: toluene-4-sulfonic acid / acetonitrile / 65 h / 20 °C

With dmap; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1021/jm300881a