N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide

Base Information

Chemical Name:N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide
CAS No.:1378523-99-9
Molecular Formula:C₂₃H₂₉NO₄S
Molecular Weight:415.554
Hs Code.:

Synonyms:N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide

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Technology Process of N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide

There total 4 articles about N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1232168-40-9
C₁₆H₂₁NO₃S

: 1378523-99-9
N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide

Guidance literature:: In tetrahydrofuran; at 5 - 28 ℃; for 0.916667h; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/ol301219c

Reference yield:

: 1220-80-0,67368-40-5,150614-61-2
(S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid

: 1378523-99-9
N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 4 h / 60 - 70 °C

2: lithium borohydride / tetrahydrofuran; ethanol / 1 h / 5 - 28 °C

3: pyridinium chlorochromate / dichloromethane / 6 h / 10 - 28 °C

4: tetrahydrofuran / 0.92 h / 5 - 28 °C

With lithium borohydride; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ol301219c

Reference yield:

: 1378523-76-2
N-(1-(hydroxymethyl)-3-methylbutyl)-4-methyl-N-prop-2-ynyl-benzenesulfonamide

: 1378523-99-9
N-{1-[hydroxy(4-methoxyphenyl)methyl]-3-methylbutyl}-4-methyl-N-prop-2-ynylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 6 h / 10 - 28 °C

2: tetrahydrofuran / 0.92 h / 5 - 28 °C

With pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol301219c