1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride

Base Information

Chemical Name:1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride
CAS No.:1055304-95-4
Molecular Formula:C₁₇H₁₆ClN₃O₂S*ClH
Molecular Weight:398.313
Hs Code.:

Synonyms:1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride

Suppliers and Price of 1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride

There total 3 articles about 1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1055306-43-8
tert-butyl {[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

: 1055304-95-4
1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; water; ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2017.04.014

Reference yield:

: 7126-39-8
pyrrole-3-carboxaldehyde

: 1055304-95-4
1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / tetrahydrofuran; N,N-dimethyl-formamide / 3.5 h / -70 - -10 °C

2.1: tetrahydrofuran; methanol / 1 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

4.2: 0.5 h / 0 - 20 °C

5.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.25 h / -78 °C

5.2: 0.5 h / -78 °C

6.1: hydrogenchloride; ethanol / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; ethanol; sodium hydride; diisopropylamine; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1055307-70-4
C₆H₉BrN₂

: 1055304-95-4
1-[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.25 h / -78 °C

3.2: 0.5 h / -78 °C

4.1: hydrogenchloride; ethanol / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; n-butyllithium; ethanol; sodium hydride; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate;