2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile

Base Information

Chemical Name:2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile
CAS No.:214492-07-6
Molecular Formula:C₁₀H₁₀FNO
Molecular Weight:179.194
Hs Code.:

Synonyms:2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile

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Chemical Property of 2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile

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Technology Process of 2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile

There total 3 articles about 2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 214491-99-3
β-(S)-(2-fluorophenyl)-γ,2-dioxo-4-(R)-phenyl-3-oxazolidinebutyronitrile

: 214492-07-6
2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile

Guidance literature:: With sodium tetrahydroborate; water; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1016/S0040-4039(98)01521-4

Reference yield:

: 451-82-1
(2-fluorophenyl)acetic acid

: 214492-07-6
2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / triethylamine; pivaloyl chloride / toluene / 5 h / 80 - 85 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -8 - 0 °C

2.2: tetrahydrofuran / 4.5 h / -20 - -15 °C

3.1: sodium borohydride / tetrahydrofuran; H₂O / 1 h / 20 - 25 °C

With sodium tetrahydroborate; pivaloyl chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; water; toluene;
DOI:10.1021/jo020256i

Reference yield:

: 216754-32-4
3-[2-(2-fluorophenyl)-1-oxoethyl]-4-(R)-phenyl-2-oxazolidinone

: 214492-07-6
2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -8 - 0 °C

1.2: tetrahydrofuran / 4.5 h / -20 - -15 °C

2.1: sodium borohydride / tetrahydrofuran; H₂O / 1 h / 20 - 25 °C

With sodium tetrahydroborate; lithium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1021/jo020256i