tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate
CAS No.:862479-40-1
Molecular Formula:C₅₃H₄₆Br₆N₄O₁₁
Molecular Weight:1394.39
Hs Code.:

tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Synonyms:tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

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Chemical Property of tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

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Technology Process of tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

There total 8 articles about tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 210880-81-2
4-hydroxyphenylpyruvic acid O-benzyloxime

: 862479-40-1
tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / N-bromosuccinimide / dimethylformamide / 2 h / 0 °C

2: 52 percent / cerium(IV) diammonium nitrate / acetonitrile; H₂O / 1 h / 0 °C

3: 82 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride / tetrahydrofuran / 6 h / 0 °C

With N-Bromosuccinimide; ammonium cerium(IV) nitrate; 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazol-hydrate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2005.05.038

Reference yield:

: 51-67-2
tyrosamine

: 862479-40-1
tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂; AcOH / 50 °C

2: 24 g / Et₃N / methanol / 2 h / 20 °C

3: 53 percent / cerium(IV) diammonium nitrate / acetonitrile; H₂O / 1 h / 0 °C

4: 0.59 g / Na₂S₂O₄ / H₂O; tetrahydrofuran / 0.17 h / 20 °C

5: 82 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride / tetrahydrofuran / 6 h / 0 °C

With sodium dithionite; ammonium cerium(IV) nitrate; 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; bromine; acetic acid; 1-hydroxybenzotriazol-hydrate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1016/j.tet.2005.05.038

Reference yield:

: 156-39-8
4-hydroxyphenylpiruvic acid

: 862479-40-1
tert-butyl (2-{4-[5-(2-{2-benzyloxyimino-3-[4-(3-benzyloxyimino-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)-3,5-dibromophenyl]propionylamino}ethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: NaOAc / ethanol / 6 h / 20 °C

2: 91 percent / N-bromosuccinimide / dimethylformamide / 2 h / 0 °C

3: 52 percent / cerium(IV) diammonium nitrate / acetonitrile; H₂O / 1 h / 0 °C

4: 82 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride / tetrahydrofuran / 6 h / 0 °C

With N-Bromosuccinimide; ammonium cerium(IV) nitrate; 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; sodium acetate; 1-hydroxybenzotriazol-hydrate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2005.05.038