(1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.1^2,5>dodeca-3-ene-4-carboxamide 8,9-acetonide

Base Information

• Chemical Name: (1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.1^2,5>dodeca-3-ene-4-carboxamide 8,9-acetonide
• CAS No.: 82783-69-5
• Molecular Formula: C₅₀H₆₃NO₇Si
• Molecular Weight: 818.138

Synonyms:(1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.1^2,5>dodeca-3-ene-4-carboxamide 8,9-acetonide

Chemical Property of (1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.1^2,5>dodeca-3-ene-4-carboxamide 8,9-acetonide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.1^2,5>dodeca-3-ene-4-carboxamide 8,9-acetonide

There total 10 articles about (1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.1^2,5>dodeca-3-ene-4-carboxamide 8,9-acetonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C24H28O7 (82770-06-7) + (2S)-(Z,E)-N,N-benzyl-2-<6-(2'-trimethylsilyl)ethoxy-4,5-dimethyl-1-phenyl>hexa-3,5-dienylamine (82495-82-7) → (1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.12,5>dodeca-3-ene-4-carboxamide 8,9-acetonide (82783-69-5)

Guidance literature:

at 25 ℃; for 1h;

DOI:10.1021/ja00385a030

Reference yield:

(1R,2S,3S,4S,6R)-2,6-dimethyl-4-(phenylsulfonyl)-4-(2-propenyl)-3-<3-(tert-butoxycarbonyl)-2-oxopropyl>cyclohexane-1,2-diol 1,2-diacetonide (82769-94-6) → (1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.12,5>dodeca-3-ene-4-carboxamide 8,9-acetonide (82783-69-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) potassium tert-butoxide, 2.) ammoniua, lithium / 1.) tert-butyl alcohol, THF, 0 deg C, 5 min, 2.) -78 deg C, 1.5 h

3: 1.) 80percent m-chloroperbenzoic acid, sodium bicarbonate / 1.) methylene chloride, 0 deg C, 25 min, 2.) pyridine, 25 deg C, 3 h

4: 94 percent / methanesulfonic acid, trifluoroacetic acid / CH₂Cl₂ / 2 h / 25 °C

5: 78 percent / 1 h / 25 °C

With methanesulfonic acid; potassium tert-butylate; ammonia; lithium; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja00385a030

Reference yield:

(1R,2S,6R)-2,6-dimethyl-4-(phenylsulfonyl)cyclohex-3-ene-1,2-diol 1,2-diacetonide (82796-49-4) → (1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.12,5>dodeca-3-ene-4-carboxamide 8,9-acetonide (82783-69-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) KDA / 1.) THF, 40 min, 2.) -25 deg C, 30 min

2: 1.) potassium tert-butoxide, 2.) ammoniua, lithium / 1.) tert-butyl alcohol, THF, 0 deg C, 5 min, 2.) -78 deg C, 1.5 h

4: 1.) 80percent m-chloroperbenzoic acid, sodium bicarbonate / 1.) methylene chloride, 0 deg C, 25 min, 2.) pyridine, 25 deg C, 3 h

5: 94 percent / methanesulfonic acid, trifluoroacetic acid / CH₂Cl₂ / 2 h / 25 °C

6: 78 percent / 1 h / 25 °C

With methanesulfonic acid; Diethoxy-methyl-(6-amino-hexylaminomethyl)-silan; potassium tert-butylate; ammonia; lithium; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja00385a030

upstream raw materials:

C₂₄H₂₈O₇

(2S)-(Z,E)-N,N-benzyl-2-<6-(2'-trimethylsilyl)ethoxy-4,5-dimethyl-1-phenyl>hexa-3,5-dienylamine

benzoyl chloride

benzoic acid anhydride

Downstream raw materials:

(1S,2R,3S,5R,6R,7S,8R,10R,11S,14R,15S,18R)-13,14-dibenzyl-18-(2-(trimethylsilyl)ethoxy)-6,7,10-trihydroxy-5,7,16,17-tetramethyl-12-oxo-13-aza-19-oxapentacyclo<9.7.0^2,10.0^3,8.0^11,15>nonadec-16-ene 6,7-acetonide

(1S,3S,5R,6R,7S,8R,10R,11S,14R,15S,18R)-13,14-dibenzyl-18-(2-(trimethylsilyl)ethoxy)-6,7,10-trihydroxy-5,7,16,17-tetramethyl-2,12-dioxo-13-azatetracyclo<9.7.0.0^3,8.0^11,15>octadec-16-ene 6,7-acetonide

(1S,3S,5R,6R,7S,8R,11S,14R,15S,18R)-13,14-dibenzyl-18-(2-(trimethylsilyl)ethoxy)-6,7-dihydroxy-5,7,16,17-tetramethyl-2,10,12-trioxo-13-azatetracyclo<9.7.0.0^3,8.0^11,15>octadec-16-ene 6,7-acetonide

C₅₀H₆₃NO₇Si

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 82783-69-5 (1S,2R,1'R,5R,7R,8S,9R,10R)-N-benzyl-N-<1'-benzyl-3',4'-dimethyl-5-<2-(trimethylsilyl)ethoxy>penta-2',4'(Z,E)-dienyl>-5-(benzoyloxy)-8,9-dihydroxy-8,10-dimethyl-12-oxatricyclo<5.4.0.1^2,5>dodeca-3-ene-4-carboxamide 8,9-acetonide

Send

Send

Metric Ton KG G Pound L ML

Send

Send