methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate

Base Information

• Chemical Name: methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate
• CAS No.: 643092-40-4
• Molecular Formula: C₂₉H₃₁ClFNO₅
• Molecular Weight: 528.02

Synonyms:methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate

Chemical Property of methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate

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Technology Process of methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate

There total 2 articles about methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate (643093-71-4) + [2-fluoro-4-(methoxycarbonyl)phenyl]boronic acid (603122-84-5) → methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate (643092-40-4)

Guidance literature:

With sodium carbonate; Ph(PPh₃)4; In 1,2-dimethoxyethane; at 70 ℃;

DOI:10.1021/jm701324c

Reference yield:

→ methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate (643092-40-4)

Guidance literature:

Reference yield:

methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-2-fluoro-1,1'-biphenyl-4-carboxylate (643092-40-4) → C28H29ClFNO5

Guidance literature:

With sodium hydroxide; In ethanol; at 40 ℃;

DOI:10.1021/jm701324c

upstream raw materials:

tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate

[2-fluoro-4-(methoxycarbonyl)phenyl]boronic acid

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