tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate

Base Information

• Chemical Name: tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate
• CAS No.: 643093-71-4
• Molecular Formula: C₂₁H₂₅BrClNO₃
• Molecular Weight: 454.791

Synonyms:tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate

Chemical Property of tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate

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Technology Process of tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate

There total 1 articles about tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R)-2-[[2-(4-Bromophenyl)ethyl]amino]-1-(3-chlorophenyl)ethanol (643093-70-3) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate (643093-71-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; pH=7 - 8;

DOI:10.1021/jm701324c

Reference yield: 94.0%

tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate (643093-71-4) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate (643094-38-6)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 120h;

DOI:10.1021/jm701324c

Reference yield: 35.0%

tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate (643093-71-4) + (5-formylthiophen-2-yl)boronic acid → tert-butyl (2R)-2-(3-chlorophenyl)-2-hydroxyethyl{2-[4-(5-formyl-2-thienyl)phenyl]ethyl}carbamate (643093-62-3)

Guidance literature:

With sodium carbonate; Ph(PPh₃)4; In 1,2-dimethoxyethane; at 70 ℃;

DOI:10.1021/jm701324c

upstream raw materials:

(1R)-2-[[2-(4-Bromophenyl)ethyl]amino]-1-(3-chlorophenyl)ethanol

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][2-[4'-[[[(3-hydroxypropyl)sulfonyl]amino]-carbonyl]-3'-isopropoxy-4-biphenylyl]ethyl]carbamate

methyl 6-[4-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]ethyl]phenyl]-2-naphthoate

methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)-1,1'-biphenyl-4-carboxylate

methyl 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino]ethyl]-2-methyl-1,1'-biphenyl-4-carboxylate

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