(E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde

Base Information

Chemical Name:(E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde
CAS No.:1429623-07-3
Molecular Formula:C₂₇H₁₈O₂S₂
Molecular Weight:438.571
Hs Code.:

Synonyms:(E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde

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Chemical Property of (E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde

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Technology Process of (E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde

There total 3 articles about (E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1429623-05-1
5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-carbaldehyde

: 115754-62-6
(1,3-dioxolan-2-ylmethyl)tributylphosphonium bromide

: 1429623-07-3
(E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde

Guidance literature:: 5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-carbaldehyde; (1,3-dioxolan-2-ylmethyl)tributylphosphonium bromide; With sodium ethanolate; In ethanol; N,N-dimethyl-formamide; at 90 ℃; for 22h; Inert atmosphere; Sealed tube;

With hydrogenchloride; water; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.tet.2013.03.027

Reference yield:

: 129806-51-5
2,6-diphenyl-(4H-pyran-4ylidene)-diphenylphosphine oxide

: 1429623-07-3
(E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -30 °C / Inert atmosphere; Sealed tube

1.2: 1 h / Inert atmosphere; Sealed tube

2.1: sodium ethanolate / N,N-dimethyl-formamide; ethanol / 22 h / 90 °C / Inert atmosphere; Sealed tube

2.2: 1.5 h / 20 °C / Inert atmosphere; Sealed tube

With n-butyllithium; sodium ethanolate; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tet.2013.03.027

Reference yield:

: 37882-75-0
2,5-Thieno<3,2-b>thiophendicarbaldehyd

: 1429623-07-3
(E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -30 °C / Inert atmosphere; Sealed tube

1.2: 1 h / Inert atmosphere; Sealed tube

2.1: sodium ethanolate / N,N-dimethyl-formamide; ethanol / 22 h / 90 °C / Inert atmosphere; Sealed tube

2.2: 1.5 h / 20 °C / Inert atmosphere; Sealed tube

With n-butyllithium; sodium ethanolate; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tet.2013.03.027