(E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione

Base Information

Chemical Name:(E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione
CAS No.:1429622-96-7
Molecular Formula:C₃₅H₂₈N₂O₃S₃
Molecular Weight:620.817
Hs Code.:

Synonyms:(E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione

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Chemical Property of (E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione

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Technology Process of (E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione

There total 4 articles about (E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 5217-47-0
N,N'-diethyl-2-thiobarbituric acid

: 1429623-07-3
(E)-3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)acrylaldehyde

: 1429622-96-7
(E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione

Guidance literature:: In ethanol; for 2h; Inert atmosphere; Reflux; Sealed tube;
DOI:10.1016/j.tet.2013.03.027

Reference yield:

: 1429623-05-1
5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-carbaldehyde

: 1429622-96-7
(E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / N,N-dimethyl-formamide; ethanol / 22 h / 90 °C / Inert atmosphere; Sealed tube

1.2: 1.5 h / 20 °C / Inert atmosphere; Sealed tube

2.1: ethanol / 2 h / Inert atmosphere; Reflux; Sealed tube

With sodium ethanolate; In ethanol; N,N-dimethyl-formamide; 2.1: |Knoevenagel Condensation;
DOI:10.1016/j.tet.2013.03.027

Reference yield:

: 37882-75-0
2,5-Thieno<3,2-b>thiophendicarbaldehyd

: 1429622-96-7
(E)-5-[3-(5-(2,6-diphenyl-4H-pyran-4-ylidenemethyl)thieno[3,2-b]thiophen-2-yl)alylidene]-1,3-diethyl-2-thioxodihydropyrimidin-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -30 °C / Inert atmosphere; Sealed tube

1.2: 1 h / Inert atmosphere; Sealed tube

2.1: sodium ethanolate / N,N-dimethyl-formamide; ethanol / 22 h / 90 °C / Inert atmosphere; Sealed tube

2.2: 1.5 h / 20 °C / Inert atmosphere; Sealed tube

3.1: ethanol / 2 h / Inert atmosphere; Reflux; Sealed tube

With n-butyllithium; sodium ethanolate; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination / 3.1: |Knoevenagel Condensation;
DOI:10.1016/j.tet.2013.03.027