4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester

Base Information

• Chemical Name: 4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester
• CAS No.: 934965-67-0
• Molecular Formula: C₁₈H₁₃BrClNO₃S₂
• Molecular Weight: 470.795
• Mol file: 934965-67-0.mol

Synonyms:4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester

Chemical Property of 4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester

There total 5 articles about 4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-bromo-2-iodo-6-methylpyridin-3-yl 4-chlorobenznesulfonate (934965-65-8) + S-Phenyl benzenethiosulfonate (1212-08-4) → 4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester (934965-67-0)

Guidance literature:

4-bromo-2-iodo-6-methylpyridin-3-yl 4-chlorobenznesulfonate; With isopropylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 0.5h;

S-Phenyl benzenethiosulfonate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2007.01.027

Reference yield:

2,4-diiodo-3-hydroxy-6-methylpyridine (934965-62-5) → 4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester (934965-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 30.05 g / triethylamine / CH₂Cl₂ / 12 h / 25 °C

2.1: i-PrMgCl / tetrahydrofuran / 0.5 h / -78 °C

2.2: 67 percent / 1,2-dibromotetrafluoroethane / tetrahydrofuran / 6 h / -78 - 20 °C

3.1: i-PrMgCl / tetrahydrofuran / 0.5 h / -78 °C

3.2: 45 percent / tetrahydrofuran / 1 h / 20 °C

With isopropylmagnesium chloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2007.01.027

Reference yield:

2,4-diiodo-6-methylpyridin-3-yl 4-chlorobenzenesulfonate (934965-61-4) → 4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester (934965-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: i-PrMgCl / tetrahydrofuran / 0.5 h / -78 °C

1.2: 67 percent / 1,2-dibromotetrafluoroethane / tetrahydrofuran / 6 h / -78 - 20 °C

2.1: i-PrMgCl / tetrahydrofuran / 0.5 h / -78 °C

2.2: 45 percent / tetrahydrofuran / 1 h / 20 °C

With isopropylmagnesium chloride; In tetrahydrofuran;

DOI:10.1016/j.tet.2007.01.027

upstream raw materials:

4-bromo-2-iodo-6-methylpyridin-3-yl 4-chlorobenznesulfonate

S-Phenyl benzenethiosulfonate

2,4-diiodo-3-hydroxy-6-methylpyridine

2,4-diiodo-6-methylpyridin-3-yl 4-chlorobenzenesulfonate