2,4-Diiodo-3-hydroxy-6-methylpyridine

Base Information

• Chemical Name: 2,4-Diiodo-3-hydroxy-6-methylpyridine
• CAS No.: 934965-62-5
• Molecular Formula: C₆H₅I₂NO
• Molecular Weight: 360.921
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00698168
• Wikidata: Q82628294
• Mol file: 934965-62-5.mol

Synonyms:2,4-DIIODO-3-HYDROXY-6-METHYLPYRIDINE;934965-62-5;2,4-diiodo-6-methylpyridin-3-ol;3-Pyridinol,2,4-diiodo-6-methyl-;DTXSID00698168;FT-0763373

Chemical Property of 2,4-Diiodo-3-hydroxy-6-methylpyridine

Chemical Property:

• PSA: 33.12000
• LogP: 2.30480
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 360.84606
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

99% ^*data from raw suppliers

2,4-DIIODO-3-HYDROXY-6-METHYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=N1)I)O)I

Technology Process of 2,4-Diiodo-3-hydroxy-6-methylpyridine

There total 2 articles about 2,4-Diiodo-3-hydroxy-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodo-6-methyl-3-pyridinol (23003-30-7) → 2,4-diiodo-3-hydroxy-6-methylpyridine (934965-62-5)

Guidance literature:

With iodine; sodium carbonate; In water; at 20 ℃;

DOI:10.1016/j.tet.2007.01.027

Reference yield:

5-Hydroxy-2-methylpyridine (1121-78-4) → 2,4-diiodo-3-hydroxy-6-methylpyridine (934965-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃; iodine / H₂O / 1 h / 20 °C

2: Na₂CO₃; iodine / H₂O / 20 °C

With iodine; sodium carbonate; In water;

DOI:10.1016/j.tet.2007.01.027

Reference yield:

2,4-diiodo-3-hydroxy-6-methylpyridine (934965-62-5) + 4-chlorobenzenesulfonyl chloride (98-60-2) → 2,4-diiodo-6-methylpyridin-3-yl 4-chlorobenzenesulfonate (934965-61-4)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 12h;

DOI:10.1016/j.tet.2007.01.027

upstream raw materials:

2-iodo-6-methyl-3-pyridinol

5-Hydroxy-2-methylpyridine

Downstream raw materials:

2,4-diiodo-6-methylpyridin-3-yl 4-chlorobenzenesulfonate

4-bromo-2-iodo-6-methylpyridin-3-yl 4-chlorobenznesulfonate

4-chlorobenzenesulfonic acid 4-bromo-6-methyl-2-phenylsulfanyl-pyridin-3-yl ester

4-chloro-benzenesulfonic acid 4-bromo-2-(4-chloro-phenylsulfanyl)-6-methylpyridin-3-yl ester