4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

Base Information

Chemical Name:4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide
CAS No.:1227911-32-1
Molecular Formula:C₂₂H₂₂N₈O₂
Molecular Weight:430.469
Hs Code.:

Synonyms:4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

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Chemical Property of 4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

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Technology Process of 4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

There total 6 articles about 4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227911-33-2
4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

: 1227911-32-1
4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

Guidance literature:: With hydrazine hydrate; In ethanol; at 80 - 90 ℃; for 22h; Sealed tube; Inert atmosphere;

Reference yield:

: 843663-18-3
(4-cyano-3-fluorophenyl)boronic acid

: 1227911-32-1
4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 95 °C

2: hydrazine hydrate / ethanol / 80 - 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; hydrazine hydrate; In 1,4-dioxane; ethanol; water; 1: Suzuki coupling;
DOI:10.1021/jm101527u

Reference yield:

: 189321-66-2
4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid

: 1227911-32-1
4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

1.2: 20 °C

2.1: methanol; ethanol / 50 - 100 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 95 °C

4.1: hydrazine hydrate / ethanol / 80 - 100 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1021/jm101527u