4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

Base Information

Chemical Name:4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide
CAS No.:1227911-33-2
Molecular Formula:C₂₂H₁₉FN₆O₂
Molecular Weight:418.43
Hs Code.:

Synonyms:4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

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Chemical Property of 4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

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Technology Process of 4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

There total 4 articles about 4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 843663-18-3
(4-cyano-3-fluorophenyl)boronic acid

: 1227911-31-0
4-(2-amino-6-chloro-4-pyrimidinyl)-N-phenyl-2-morpholinecarboxamide

: 1227911-33-2
4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 95 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 189321-66-2
4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid

: 1227911-33-2
4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

1.2: 20 °C

2.1: methanol; ethanol / 50 - 100 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 95 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1021/jm101527u

Reference yield:

: C₂HF₃O₂*C₁₁H₁₄N₂O₂

: 1227911-33-2
4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; ethanol / 50 - 100 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; methanol; ethanol; water; 2: Suzuki coupling;
DOI:10.1021/jm101527u