1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole

Base Information

• Chemical Name: 1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole
• CAS No.: 1225039-35-9
• Molecular Formula: C₁₃H₁₆IN₃O₃S
• Molecular Weight: 421.259

Synonyms:1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole

Chemical Property of 1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole

Chemical Property:

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Technology Process of 1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole

There total 1 articles about 1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

p-Methoxybenzyl bromide (2746-25-0) + 4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (198127-92-3) → 1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole (1225039-35-9)

Guidance literature:

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide; With ethylmagnesium bromide; In diethyl ether; dichloromethane; at 20 ℃; for 0.333333h;

p-Methoxybenzyl bromide; With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; diethyl ether; dichloromethane; at 20 ℃; for 48h;

DOI:10.1039/b926285g

Reference yield: 70.0%

1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole (1225039-35-9) + 2-(benzyloxy)-5-(bromomethyl)-1,3-dimethoxybenzene (111194-05-9) → 4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide (1225039-36-0)

Guidance literature:

With copper(I) cyanide di(lithium chloride); ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1039/b926285g

Reference yield:

1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole (1225039-35-9) → C30H36N3O6S(1+)*CF3O3S(1-)

Guidance literature:

Multi-step reaction with 2 steps

1: ethylmagnesium bromide; copper(I) cyanide di(lithium chloride) / diethyl ether; dichloromethane; tetrahydrofuran

2: dichloromethane / 4 h / 0 °C / Inert atmosphere

With copper(I) cyanide di(lithium chloride); ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.bmc.2017.01.024

upstream raw materials:

p-Methoxybenzyl bromide

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide

Downstream raw materials:

4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

5-(4-benzyloxy-3,5-dimethoxybenzyl)-4-(4-methoxy-benzyl)-1-methyl-1H-imidazole

2-azido-5-(4-benzyloxy-3,5-dimethoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazole

4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,6-dimethoxyphenol

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