4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

Base Information

• Chemical Name: 4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide
• CAS No.: 1225039-36-0
• Molecular Formula: C₂₉H₃₃N₃O₆S
• Molecular Weight: 551.664
• Mol file: 1225039-36-0.mol

Synonyms:4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

Chemical Property of 4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

There total 3 articles about 4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole (1225039-35-9) + 2-(benzyloxy)-5-(bromomethyl)-1,3-dimethoxybenzene (111194-05-9) → 4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide (1225039-36-0)

Guidance literature:

With copper(I) cyanide di(lithium chloride); ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1039/b926285g

Reference yield:

p-Methoxybenzyl bromide (2746-25-0) → 4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide (1225039-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / diethyl ether; dichloromethane / 0.33 h / 20 °C

1.2: 48 h / 20 °C

2.1: ethylmagnesium bromide; copper(I) cyanide di(lithium chloride) / diethyl ether; dichloromethane; tetrahydrofuran

With copper(I) cyanide di(lithium chloride); ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.bmc.2017.01.024

Reference yield:

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (198127-92-3) → 4-(4-benzyloxy-3,5-dimethoxybenzyl)-5-(4-methoxybenzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide (1225039-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / diethyl ether; dichloromethane / 0.33 h / 20 °C

1.2: 48 h / 20 °C

2.1: ethylmagnesium bromide; copper(I) cyanide di(lithium chloride) / diethyl ether; dichloromethane; tetrahydrofuran

With copper(I) cyanide di(lithium chloride); ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.bmc.2017.01.024

upstream raw materials:

1-(N,N-dimethylaminosulfonyl)-4-iodo-5-(4-methoxy-benzyl)-1H-imidazole

2-(benzyloxy)-5-(bromomethyl)-1,3-dimethoxybenzene

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide

p-Methoxybenzyl bromide

Downstream raw materials:

5-(4-benzyloxy-3,5-dimethoxybenzyl)-4-(4-methoxy-benzyl)-1-methyl-1H-imidazole

2-azido-5-(4-benzyloxy-3,5-dimethoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazole

naamidine H

4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,6-dimethoxyphenol