methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate

Base Information

• Chemical Name: methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate
• CAS No.: 509150-80-5
• Molecular Formula: C₄₁H₅₈N₆O₆
• Molecular Weight: 730.948
• Mol file: 509150-80-5.mol

Synonyms:methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate

Chemical Property of methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate

There total 4 articles about methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoic acid (188777-46-0,313672-19-4) + 2-{N-benzyl-N'-[2-(N-benzyl-hydrazino)-propionyl]-hydrazino}-4-methyl-pentanoic acid methyl ester; compound with trifluoro-acetic acid → methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate (509150-80-5)

Guidance literature:

With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 46h;

DOI:10.1002/hlca.200390342

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate (509150-80-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaOH; water / 20 °C

1.2: 86 percent / NaBH₄ / 0 °C

2.1: Et₄NOH / methanol

2.2: 65 percent / CH₂Cl₂ / cooling

3.1: 2.15 g / N-methylmorpholine; HATU / dimethylformamide / 46 h / 0 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; water; tetraethylammonium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200390342

Reference yield:

(S)-2-(benzylamino)-3-methylbutanoic acid (15363-84-5) → methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate (509150-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₄NOH / methanol

1.2: 65 percent / CH₂Cl₂ / cooling

2.1: 2.15 g / N-methylmorpholine; HATU / dimethylformamide / 46 h / 0 - 20 °C

With 4-methyl-morpholine; tetraethylammonium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200390342

upstream raw materials:

(S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoic acid

L-valine

(S)-2-(benzylamino)-3-methylbutanoic acid

benzaldehyde

Downstream raw materials:

C₇₆H₁₀₄N₁₂O₉

(S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid