ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate
• CAS No.: 933786-11-9
• Molecular Formula: C₁₅H₁₄ClNO₃
• Molecular Weight: 291.734
• Mol file: 933786-11-9.mol

Synonyms:ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate

There total 1 articles about ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 1H-pyrrole-2-carboxylate (2199-43-1) + 3-chloro-benzeneacetyl chloride (41904-39-6) → ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate (933786-11-9)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm061381f

Reference yield:

ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate (933786-11-9) → 4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-N-ethyl-N-methyl-1H-pyrrole-2-carboxamide

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylformamide / 20 °C

2: 78 percent / hydrazine hydrate / dimethylformamide / 60 °C

3: 83 percent / aq. NaOH / ethanol / 60 °C

4: EDCI; HOBt; DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm061381f

Reference yield:

ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate (933786-11-9) → 4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylformamide / 20 °C

2: 78 percent / hydrazine hydrate / dimethylformamide / 60 °C

3: 83 percent / aq. NaOH / ethanol / 60 °C

4: EDCI; HOBt; DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm061381f

upstream raw materials:

ethyl 1H-pyrrole-2-carboxylate

3-chloro-benzeneacetyl chloride

Downstream raw materials:

4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxylic acid

ethyl 4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxylate