41904-39-6

Basic information

• Product Name: 2-(3-chlorophenyl)acetyl chloride
• Synonyms: 2-(3-chlorophenyl)acetyl chloride
• CAS NO: 41904-39-6
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.03864
• Mol File: 41904-39-6.mol
• Article Data: 61

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-chlorophenyl)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chlorophenyl)acetyl chloride(41904-39-6)
• EPA Substance Registry System: 2-(3-chlorophenyl)acetyl chloride(41904-39-6)

Safety Data

• Hazardous Substances Data: 41904-39-6(Hazardous Substances Data)

Usage

Uses

2-(3-Chlorophenyl)acetyl chloride is a novel pyrrolidine MCHR1 antagonists and reduce hERG inhibition.

Upstream product

• 53088-68-9 methyl 3-chlorophenylacetate 
• 64123-83-7 methyl 2-(3-chlorophenyl)acrylate 
• 107473-99-4 2-(3-chlorophenyl)acrylic acid 
• 14338-36-4 3-amino phenylacetic acid 
• 535-80-8 3-chlorobenzoate 
• 618-46-2 m-Chlorobenzoyl chloride 
• 7023-78-1 2-diazo-1-(3-chlorophenyl)ethanone 
• 1878-65-5 3-chlorophenylacetic acid 

Downstream Products

• 68968-12-7 2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one 
• 21922-62-3 3-Chlor-phenylessigsaeure-N-<2-(3,4-dimethoxyphenyl)-ethylamid> 
• 854920-11-9 dimethyl (E)-2-(3-chlorobenzylidene)succinate 
• 221122-22-1 4-(3-chlorophenyl)-3-oxobutyric acid ethyl ester 
• 449732-58-5 2,2,2-trichloro-1-(4-(3-chlorophenyl)acetyl-1H-pyrrol-2-yl)-ethanone 
• 1160619-93-1 tert-butyl (S)-N-[2-(4-{[2-(3-chlorophenyl)acetyl]amino}phenyl)ethyl]-N-{2-hydroxy-3-[4-(methoxymethoxy)phenoxy]propyl}carbamate 
• 864273-05-2 3-(3-chlorophenyl)acetyl-1-phenylsulfonylpyrrole 
• 259211-71-7 5-(3-chloro-phenyl-acetyl)-amino-3-ethyl4-ethoxycarbonyl-l-methyl-pyrazole 

Relevant articles and documents

Photoredox Catalyzed Sulfonylation of Multisubstituted Allenes with Ru(bpy)3Cl2 or Rhodamine B

A highly regio- and stereoselective sulfonylation of allenes was developed that provided direct access to α, β-substituted unsaturated sulfone. By means of visible-light photoredox catalysis, the free radicals produced by p-toluenesulfonic acid reacted with multisubstituted allenes to obtain Markovnikov-type vinyl sulfones with Ru(bpy)3Cl2 or Rhodamine B as photocatalyst. The yield of this reaction could reach up to 91%. A series of unsaturated sulfones would be used for further transformation to some valuable compounds.

Design, synthesis, biological evaluation and silico prediction of novel sinomenine derivatives

Sinomenine is a morphinan alkaloid with a variety of biological activities. Its derivatives have shown significant cytotoxic activity against different cancer cell lines in many studies. In this study, two series of sinomenine derivatives were designed and synthesized by modifying the active positions C1 and C4 on the A ring of sinomenine. Twenty‐three compounds were synthesized and characterized by spectroscopy (IR,1H‐NMR,13C‐NMR, and HRMS). They were further evaluated for their cytotoxic activity against five cancer cell lines, MCF‐7, Hela, HepG2, SW480 and A549, and a normal cell line, Hek293, using MTT and CCK8 methods. The chlorine‐containing compounds exhibited significant cytotoxic activity compared to the nucleus structure of sinomenine. Furthermore, we searched for cancer‐related core targets and verified their interaction with derivatives through molecular docking. The chlorine‐containing compounds 5g, 5i, 5j, 6a, 6d, 6e, and 6g exhibited the best against four core targets AKT1, EGFR, HARS and KARS. The molecular docking results were consistent with the cytotoxic results. Overall, results indicate that chlorine‐containing derivatives might be a promising lead for the development of new anticancer agents.

CEPHALOSPORIN CIPROFLOXACIN HYBRID COMPOUNDS

A compound of formula (Ia) and related aspects.