3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid

Base Information

Chemical Name:3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid
CAS No.:1561811-54-8
Molecular Formula:C₁₈H₁₂FN₅O₂
Molecular Weight:349.324
Hs Code.:

Synonyms:3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid

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Chemical Property of 3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid

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Technology Process of 3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid

There total 8 articles about 3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1561811-19-5
2-chloro-4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazine

: 455-87-8
4-amino-3-fluorobenzoic acid

: 1561811-54-8
3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; for 17h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2013.12.055

Reference yield: 55.0%

: 1561811-54-8
3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; for 17h; Reflux;

Reference yield:

: 159326-66-6
N-amino-1H-pyrrole-2-carbonitrile

: 1561811-54-8
3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; water / 20 °C

2.1: pyridine / 1,4-dioxane / 0.25 h

2.2: 1 h / Reflux

3.1: sodium ethanolate / ethanol / 2 h / Reflux

4.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 24 h / 120 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 7 h / Reflux; Inert atmosphere

6.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 17 h / Inert atmosphere; Reflux

With pyridine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium ethanolate; sodium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; toluene; 5.1: |Stille Cross Coupling / 6.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.12.055