455-87-8

Basic information

• Product Name: 4-AMINO-3-FLUOROBENZOIC ACID
• Synonyms: 4-amino-3-fluoro-benzoicaci;4-AMINO-3-FLUOROBENZENECARBOXYLIC ACID;4-AMINO-3-FLUOROBENZOIC ACID;BUTTPARK 44\09-60;3-FLUORO-4-AMINOBENZOIC ACID;4-Amino-3-Fluorobenzoic;NSC 25758;4-AMINO-3-FLUOROBENZ
• CAS NO: 455-87-8
• Molecular Formula: C₇H₆FNO₂
• Molecular Weight: 155.1264432
• EINECS: 207-250-1
• Product Categories: Amines;blocks;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Aromatics Compounds;Aromatics;Fluorine series
• Mol File: 455-87-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 215-218°C
• Boiling Point: 320.8 °C at 760 mmHg
• Flash Point: 147.8 °C
• Appearance: /
• Density: 1.43 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Hot Water
• PKA: 4.52±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-3-FLUOROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-3-FLUOROBENZOIC ACID(455-87-8)
• EPA Substance Registry System: 4-AMINO-3-FLUOROBENZOIC ACID(455-87-8)

Safety Data

• Hazard Codes: Xi
• RTECS: DG2525000
• HazardClass: IRRITANT
• Hazardous Substances Data: 455-87-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H6FNO2/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3H,9H2,(H,10,11)

Upstream product

• 63069-50-1 4-cyano-2-fluoroaniline 
• 403-21-4 3-fluoro-4-nitrobenzoic acid 
• 7439-89-6 iron 
• 326-67-0 N-(2-fluoro-4-methylphenyl)acetamide 
• 352-70-5 m-Fluorotoluene 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 713-11-1 4-acetamido-3-fluorobenzoic acid 

Downstream Products

• 209960-85-0 (4-amino-3-fluorophenyl)pyrrolidin-1-ylmethanone 
• 1561811-54-8 3-fluoro-4-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid 
• 103842-00-8 N-(2-fluoro-4-hydroxyphenyl)acetamide 
• 1123172-01-9 4-amino-3-fluoro-5-iodobenzoic acid methyl ester 
• 185629-32-7 methyl 4-amino-3-fluorobenzene carboxylate 
• 90663-31-3 4-amino-3-fluoro-N-methylbenzamide 

Relevant articles and documents

Preparation method of 4-amino-3-fluorobenzoic acid

The invention relates to a preparation method of 4-amino-3-fluorobenzoic acid, which is characterized in that 4-amino-3-fluorobenzoic acid is prepared by taking 3,4-difluorobenzonitrile as a raw material, and perferably, the preparation method comprises the following steps: (1) allowing 3,4-difluorobenzonitrile to react with ammonia to form an intermediate, 3-fluorine-4-aminobenzonitrile, and (2)allowing the intermediate, 3-fluorine-4-aminobenzonitrile, to give a hydrolysis reaction under an alkaline condition to form 4-amino-3-fluorobenzoic acid. The preparation method takes cheap 3,4-difluorobenzonitrile as a main raw material, synthesizes 4-amino-3-fluorobenzoic acid with high yield and high purity through steps of ammoniation and hydrolysis, has the advantages of convenience in operation, low price and low environmental pollution, and can achieve large-scale industrial production.

Substituted 3-fluorophenyl methanol compound, pharmaceutical composition and application

The invention relates to a substituted 3-fluorophenyl methanol compound, a pharmaceutical composition and application in the field of chemical pharmacy. The invention relates to the substituted 3-fluorophenyl methanol compound. Compared with valganciclovir and ganciclovir, the effectiveness of the compound is obviously strengthened, the safety performance is greatly improved, the selectivity index is obviously improved, and huge application value is achieved. The invention further discloses application of the substituted 3-fluorophenyl methanol compound serving as an antiviral drug, and specially for application in preparing a drug for preventing and treating cytomegaloviruses. The invention further discloses a pharmaceutical composition containing the compound and application in preparing the drug for treating or preventing the cytomegalovirus infection disease by utilizing the substituted 3-fluorophenyl methanol compound or the pharmaceutical composition thereof.

Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists

A compound of the following formula: and the salts thereof wherein A is hydrogen, halo, or hydroxy, broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1is optionally substituted phenyl; Ar2is aryl or heteroaryl selected from phenyl, napththyl, or pyridyl, the aryl or heteroaryl being optionally substituted; R1is hydrogen, hydroxy, or C1-C4alkyl; and R2and R3are independently selected from optionally substituted C1-C7alkyl, C3-C6cycloalkyl, C2-C6alkenyl, C2-C6alkynyl, or R2and R3, together with the nitrogen atom to which they are attached, form an optionally substituted pyrrolidine. These compounds are useful as kappa agonists.