(3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene

Base Information

Chemical Name:(3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene
CAS No.:229981-21-9
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:(3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene

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Technology Process of (3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene

There total 3 articles about (3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 99113-30-1
((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester

: 107-30-2
chloromethyl methyl ether

: 229981-21-9
(3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.) 0 deg C, 1 h, 2.) room temperature, 8 h;
DOI:10.1021/jo990200x

Reference yield:

: 124915-64-6
(4S,5R)-5-ethenyl-4-phenylmethyloxazolidin-2-one

: 229981-21-9
(3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Et₃N, DMAP / tetrahydrofuran / 5.5 h / Ambient temperature

2: 76 percent / Cs₂CO₃ / methanol / 25 h / Ambient temperature

3: 95 percent / i-Pr₂NEt / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temperature, 8 h

With dmap; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo990200x

Reference yield:

: 229981-17-3
(4S,5R)-N-(tert-butyloxycarbonyl)-5-ethenyl-4-phenylmethyl oxazolidin-2-one

: 229981-21-9
(3R,4S)-N-(tert-butoxycarbonyl)-4-amino-3-(methoxymethoxy)-5-phenylpent-1-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / Cs₂CO₃ / methanol / 25 h / Ambient temperature

2: 95 percent / i-Pr₂NEt / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temperature, 8 h

With caesium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/jo990200x