((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester

Base Information

• Chemical Name: ((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester
• CAS No.: 99113-30-1
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.364
• Mol file: 99113-30-1.mol

Synonyms:((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester

Chemical Property of ((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester

There total 18 articles about ((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

vinyl magnesium bromide (1826-67-1) + Boc-L-phenylalaninal (72155-45-4) → 4-<<(tert-butyloxy)carbonyl>amino>-3-hydroxy-5-phenyl-1-pentene (99113-28-7,99113-30-1,134806-63-6,139397-08-3,144239-49-6,144239-98-5)

Guidance literature:

With copper acetylacetonate; sodium tetrahydroborate; In methanol; ethanol; at 20 ℃; for 12h;

DOI:10.1021/ol0612760

Reference yield: 98.0%

Acetic acid (R)-1-((S)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-allyl ester (156048-63-4) → ((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester (99113-30-1)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 1h;

Reference yield: 76.0%

(4S,5R)-N-(tert-butyloxycarbonyl)-5-ethenyl-4-phenylmethyl oxazolidin-2-one (229981-17-3) → ((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester (99113-30-1)

Guidance literature:

With caesium carbonate; In methanol; for 25h; Ambient temperature;

DOI:10.1021/jo990200x

upstream raw materials:

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

vinyl magnesium bromide

Boc-Phe-OH N,O-dimethyl hydroxamate

Boc-L-phenylalaninal

Downstream raw materials:

[(S)-1-(3-Benzyl-oxiranyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

(3-Azido-1-benzyl-2-hydroxy-4-phenyl-butyl)-carbamic acid tert-butyl ester

(2R,3R,4S)-2-amino-4-<<(tert-butyloxy)carbonyl>amino>-1,5-diphenyl-3-hydroxypentane

(2S,3S,4S)-2-amino-4-<<(tert-butyloxy)carbonyl>amino>-1,5-diphenyl-3-hydroxypentane