cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide

Base Information

• Chemical Name: cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide
• CAS No.: 1448015-76-6
• Molecular Formula: C₁₉H₁₇N₃OS
• Molecular Weight: 335.429
• Mol file: 1448015-76-6.mol

Synonyms:cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide

Chemical Property of cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide

There total 3 articles about cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine (1012084-56-8) + cyclopropanecarboxylic acid [4-(4-bromophenyl)thiazol-2-yl]amide (313405-50-4) → cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide (1448015-76-6)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/cmdc.201300007

Reference yield:

4-(4-bromophenyl)-1,3-thiazol-2-amine (2103-94-8) → cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide (1448015-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

2: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane;

DOI:10.1002/cmdc.201300007

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) → cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide (1448015-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

3: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine; In 1,4-dioxane; ethanol; dichloromethane; 1: |Hantzsch Thiazole Synthesis;

DOI:10.1002/cmdc.201300007

upstream raw materials:

2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

cyclopropanecarboxylic acid [4-(4-bromophenyl)thiazol-2-yl]amide

4-(4-bromophenyl)-1,3-thiazol-2-amine

para-bromophenacyl bromide