2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide

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Chemical Name:2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide
CAS No.:1341219-63-3
Molecular Formula:C₂₈H₂₉N₃O₇
Molecular Weight:519.554
Hs Code.:

Synonyms:2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide

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Chemical Property of 2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide

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Technology Process of 2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide

There total 9 articles about 2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1341219-62-2
2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-acetoxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

: 1341219-63-3
2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: With trifluoroacetic acid; In water; at 20 ℃; for 0.5h;
DOI:10.1021/jo201495w

Reference yield:

: 912296-79-8
N-benzoyl-N-(2,4-dimethoxybenzyl)glycine benzyl ester

: 1341219-63-3
2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C / Microwave irradiation

4: dmap; triethylamine / acetonitrile / 0.17 h / 0 °C

5: trifluoroacetic acid / water / 0.5 h / 20 °C

With dmap; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo201495w

Reference yield:

: C₂₃H₃₄N₂O₄Si

: 1341219-63-3
2-[N-(2-N-benzoylaminoacetyl)-N-(4-acetoxy-2-methoxybenzyl)]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C / Microwave irradiation

3: dmap; triethylamine / acetonitrile / 0.17 h / 0 °C

4: trifluoroacetic acid / water / 0.5 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jo201495w