2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

Base Information

Chemical Name:2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide
CAS No.:1341219-59-7
Molecular Formula:C₄₁H₅₁N₃O₈Si
Molecular Weight:741.957
Hs Code.:

Synonyms:2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

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Chemical Property of 2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

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Technology Process of 2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

There total 6 articles about 2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1341219-58-6
2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetic acid

: C₂₃H₃₄N₂O₄Si

: 1341219-59-7
2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo201495w

Reference yield:

: 912296-79-8
N-benzoyl-N-(2,4-dimethoxybenzyl)glycine benzyl ester

: 1341219-59-7
2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1021/jo201495w

Reference yield:

: 129742-36-5
(4-((tert-butyldimethylsilyl)oxy)-2-methoxybenzaldehyde)

: 1341219-59-7
2-[N-[2-[N-benzoyl-N-(2,4-dimethoxybenzyl)]aminoacetyl]-N-[4-tert-butyldimethylsiloxy-2-methoxybenzyl]]amino-N-(4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 0.33 h / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / 0 - 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With dmap; sodium tris(acetoxy)borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jo201495w