[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone

Base Information

• Chemical Name: [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone
• CAS No.: 436809-77-7
• Molecular Formula: C₂₁H₁₆ClNO₂S
• Molecular Weight: 381.883

Synonyms:[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone

Chemical Property of [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone

There total 2 articles about [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iodobenzoic acid chloride (1711-02-0) → [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone (436809-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2.1: i-PrMgBr / tetrahydrofuran / 1 h / -15 °C

2.2: 97 percent / tetrahydrofuran / 3 h / -15 °C

With isopropylmagnesium bromide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0968-0896(01)00066-9

Reference yield:

4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (213462-12-5) → [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone (436809-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2.1: i-PrMgBr / tetrahydrofuran / 1 h / -15 °C

2.2: 97 percent / tetrahydrofuran / 3 h / -15 °C

With isopropylmagnesium bromide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0968-0896(01)00066-9

Reference yield: 87.0%

[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-formylphenyl)-methanone (436809-77-7) → [4-(4-chloro-phenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-(4-hydroxymethyl-phenyl)-methanone (308287-51-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 0.416667h;

DOI:10.1016/S0968-0896(01)00066-9

upstream raw materials:

4-iodobenzoic acid chloride

4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Downstream raw materials:

[4-(4-chloro-phenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-(4-hydroxymethyl-phenyl)-methanone

(4-aminomethyl-phenyl)-[4-(4-chloro-phenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-methanone

[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone

(4-azidomethyl-phenyl)-[4-(4-chloro-phenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-methanone

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