[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone

Base Information

Chemical Name:[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone
CAS No.:436809-78-8
Molecular Formula:C₂₁H₁₇Cl₂NOS
Molecular Weight:402.344
Hs Code.:

Synonyms:[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone

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Chemical Property of [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone

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Technology Process of [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone

There total 4 articles about [4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 308287-51-6
[4-(4-chloro-phenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-(4-hydroxymethyl-phenyl)-methanone

: 436809-78-8
[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone

Guidance literature:: With thionyl chloride; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/S0968-0896(01)00066-9

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 436809-78-8
[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2.1: i-PrMgBr / tetrahydrofuran / 1 h / -15 °C

2.2: 97 percent / tetrahydrofuran / 3 h / -15 °C

3.1: 87 percent / NaBH₄ / methanol / 0.42 h / 0 - 20 °C

4.1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

With sodium tetrahydroborate; thionyl chloride; isopropylmagnesium bromide; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00066-9

Reference yield:

: 213462-12-5
4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 436809-78-8
[4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-yl]-(4-chloromethylphenyl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2.1: i-PrMgBr / tetrahydrofuran / 1 h / -15 °C

2.2: 97 percent / tetrahydrofuran / 3 h / -15 °C

3.1: 87 percent / NaBH₄ / methanol / 0.42 h / 0 - 20 °C

4.1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

With sodium tetrahydroborate; thionyl chloride; isopropylmagnesium bromide; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00066-9