3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester

Base Information

• Chemical Name: 3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester
• CAS No.: 170216-40-7
• Molecular Formula: C₁₉H₂₃O₇P
• Molecular Weight: 394.361
• Mol file: 170216-40-7.mol

Synonyms:3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester

Chemical Property of 3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester

There total 3 articles about 3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

α-(Dibenzyloxooxophosphoriomethyl)acrylic acid methyl ester (170216-48-5) → 3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester (170216-40-7)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In 1,4-dioxane; for 19h; Ambient temperature;

DOI:10.7164/antibiotics.48.1134

Reference yield:

methyl 2-(bromomethyl)propenoate (4224-69-5) → 3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester (170216-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 5 min, 2.) 0 deg C, 2 h; r.t., 12 h

2: 92 percent / OsO₄, N-methylmorpholine N-oxide / dioxane / 19 h / Ambient temperature

With osmium(VIII) oxide; sodium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.7164/antibiotics.48.1134

Reference yield:

Dibenzyl phosphite (17176-77-1) → 3-Dibenzyloxooxophosphorio-2-hydroxy-2-hydroxymethylpropionic acid methyl ester (170216-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 5 min, 2.) 0 deg C, 2 h; r.t., 12 h

2: 92 percent / OsO₄, N-methylmorpholine N-oxide / dioxane / 19 h / Ambient temperature

With osmium(VIII) oxide; sodium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.7164/antibiotics.48.1134

upstream raw materials:

α-(Dibenzyloxooxophosphoriomethyl)acrylic acid methyl ester

methyl 2-(bromomethyl)propenoate

Dibenzyl phosphite

Downstream raw materials:

2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester