13-cyclohexyl-N₆-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N₆-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide

Base Information

• Chemical Name: 13-cyclohexyl-N₆-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N₆-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide
• CAS No.: 945685-65-4
• Molecular Formula: C₃₃H₄₃N₅O₅S
• Molecular Weight: 621.801

Synonyms:13-cyclohexyl-N₆-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N₆-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide

Chemical Property of 13-cyclohexyl-N₆-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N₆-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide

Chemical Property:

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Technology Process of 13-cyclohexyl-N₆-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N₆-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide

There total 2 articles about 13-cyclohexyl-N₆-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N₆-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid (902148-42-9) + N,N',N'-trimethylenediamine (142-25-6) → 13-cyclohexyl-N6-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N6-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide (945685-65-4)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

13-cyclohexyl-10-[[[(dimethylamino)sulfonyl]amino]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid methyl ester (902148-54-3) → 13-cyclohexyl-N6-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N6-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide (945685-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 0.25 h / 80 °C / Microwave irradiation

1.2: 20 °C

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With water; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

13-cyclohexyl-N6-(2-(dimethylamino)ethyl)-N-((dimethylamino)sulfonyl)-N6-methyl-3-(methyloxy)-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide (945685-65-4) → rac-(5R,6S)-13-cyclohexyl-N6-(2-(dimethylamino)ethyl)-N10-((dimethylamino)sulfonyl)-5,6-dihydroxy-N6-methyl-3-(methyloxy)-6,7-dihydro-5H-indolo[2,1-a][2]benzazepine-6,10-dicarboxamide

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃;

upstream raw materials:

13-cyclohexyl-10-[[((dimethylamino)sulfonyl)amino]carbonyl]-3-methoxy-7H-indolo[2,1a][2]benzazepine-6-carboxylic acid

N,N',N'-trimethylenediamine

13-cyclohexyl-10-[[[(dimethylamino)sulfonyl]amino]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid methyl ester

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