2-Ethoxy-4-methyl-3,4-dihydropyran

Base Information

• Chemical Name: 2-Ethoxy-4-methyl-3,4-dihydropyran
• CAS No.: 10138-44-0
• Molecular Formula: C8H14 O2
• Molecular Weight: 142.198
• Hs Code.: 2932999099
• NSC Number: 84208
• UNII: 77Y62D7K9X
• DSSTox Substance ID: DTXSID70906101
• Nikkaji Number: J35.388D
• Wikidata: Q27266613
• Mol file: 10138-44-0.mol

Synonyms:2-ethoxy-4-methyl-3,4-dihydro-2H-pyran;2-Ethoxy-4-methyl-3,4-dihydropyran;10138-44-0;2-Ethoxy-4-methyl-2,3-dihydro-4H-pyran;2H-Pyran, 2-ethoxy-3,4-dihydro-4-methyl-;NSC 84208;2-Ethoxy-3,4-dihydro-4-methyl-2H-pyran;UNII-77Y62D7K9X;2H-Pyran, 3,4-dihydro-2-ethoxy-4-methyl-;77Y62D7K9X;NSC-84208;NSC84208;SCHEMBL3676067;2H-Pyran,4-dihydro-4-methyl-;DTXSID70906101;WLN: T6O BUTJ D1 FO2;AKOS006278444;2H-Pyran,4-dihydro-2-ethoxy-4-methyl-;LS-127315;Q27266613

Chemical Property of 2-Ethoxy-4-methyl-3,4-dihydropyran

Chemical Property:

• Vapor Pressure: 0.986mmHg at 25°C
• Boiling Point: 184.8°Cat760mmHg
• Flash Point: 58.3°C
• PSA: 18.46000
• Density: 0.95g/cm³
• LogP: 1.91910
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 142.099379685
• Heavy Atom Count: 10
• Complexity: 120

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-ETHOXY-4-METHYL-3,4-DIHYDRO-2H-PYRAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Moderately toxic by ingestion. mild skin and eye irritant.
• Hazard Codes: Moderately toxic by ingestion. mild skin and eye irritant.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1CC(C=CO1)C

Technology Process of 2-Ethoxy-4-methyl-3,4-dihydropyran

There total 6 articles about 2-Ethoxy-4-methyl-3,4-dihydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trans-Crotonaldehyde (123-73-9,4170-30-3) + ethyl vinyl ether (109-92-2,25104-37-4) → (2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran (10138-44-0,17322-76-8,17322-77-9)

Guidance literature:

1,3,5-tris(1,1,1-trifluorohexane-2,4-dione-6-yl)benzene yttrium; for 72h;

DOI:10.1139/v96-195

Reference yield: 88.0%

ethyl vinyl ether (109-92-2,25104-37-4) + crotonaldehyde (123-73-9,4170-30-3) → (2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran (10138-44-0,17322-76-8,17322-77-9)

Guidance literature:

With (tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato))ytterbium(III); at 45 - 100 ℃;

DOI:10.1016/j.tet.2009.04.013

Reference yield:

ethyl vinyl ether (109-92-2,25104-37-4) + crotonaldehyde (123-73-9,4170-30-3) → 2-ethoxy-4-methyl-3,4-dihydro-2H-pyran (10138-44-0)

Guidance literature:

With ytterbium trifluoromethanesulfonate; In ethylene glycol; at 60 ℃; for 24h; under 2250180 Torr;

DOI:10.1039/b000241k

upstream raw materials:

trans-Crotonaldehyde

ethyl vinyl ether

crotonaldehyde

Downstream raw materials:

picoline

3-methylpentanedial

3-methyl-1,5-dibromopentane

3-methylpentane-1,5-diol