di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

Base Information

Chemical Name:di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate
CAS No.:723278-14-6
Molecular Formula:C₃₇H₅₀FN₆O₇PS
Molecular Weight:772.878
Hs Code.:

di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

Synonyms:di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

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Chemical Property of di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

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Technology Process of di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

There total 15 articles about di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: phosphorous acid di-tert-butyl ester 1-[3-(4-{5-[(3-fluoro-phenylcarbamoyl)-methyl]-thiazol-2-ylamino}-6-methoxy-quinazolin-7-yloxy)-propyl]-piperidin-4-ylmethyl ester

: 723278-14-6
di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

Guidance literature:: With dihydrogen peroxide; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1021/jm050786h

Reference yield:

: (E)-N'-(2-cyano-5-hydroxy-4-methoxyphenyl)-N,N-dimethylformimidamide

: 723278-14-6
di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / Cs₂CO₃ / acetonitrile / 0.5 h / 85 °C

2: 82 percent / AcOH / 3 h / 135 °C

3: 44 percent / KI / N,N-dimethyl-acetamide; 1-methyl-pyrrolidin-2-one / 80 °C

4: tetrazole / N,N-dimethyl-acetamide / 2 h / 20 °C

5: 66.6 g / aq. H₂O₂ / N,N-dimethyl-acetamide / 2 h / 20 °C

With 1H-tetrazole; dihydrogen peroxide; caesium carbonate; acetic acid; potassium iodide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/jm050786h

Reference yield:

: 385785-31-9
2-(2-amino-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide

: 723278-14-6
di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / AcOH / 3 h / 135 °C

2: 44 percent / KI / N,N-dimethyl-acetamide; 1-methyl-pyrrolidin-2-one / 80 °C

3: tetrazole / N,N-dimethyl-acetamide / 2 h / 20 °C

4: 66.6 g / aq. H₂O₂ / N,N-dimethyl-acetamide / 2 h / 20 °C

With 1H-tetrazole; dihydrogen peroxide; acetic acid; potassium iodide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide;
DOI:10.1021/jm050786h