N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide

Base Information

• Chemical Name: N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide
• CAS No.: 1421037-09-3
• Molecular Formula: C₂₆H₂₂BrN₃O₇
• Molecular Weight: 568.381
• Mol file: 1421037-09-3.mol

Synonyms:N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide

Chemical Property of N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide

There total 2 articles about N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

tyrosamine (51-67-2) + N,N'-bis(2-hydroxyethyl)-2,6-dibromonaphthalene-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide (1421037-02-6) → N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide (1421037-09-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/chem.201203097

Reference yield:

2,6-dibromo-1,4,5,8-naphthalenetetracarboxylic acid dianhydride (83204-68-6) → N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide (1421037-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 0.5 h / 130 °C

2: N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With acetic acid; In N,N-dimethyl-formamide;

DOI:10.1002/chem.201203097

Reference yield:

N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(4-hydroxyphenyl)ethylamino)-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide (1421037-09-3) → N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(3-(trimethylamino)methyl-4-hydroxyphenyl)ethylamino)-1,4,5,8-naphthalenetetracarboxylic acid 1,8:4,5-diimide iodide (1421037-21-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 2 h / Reflux; Inert atmosphere

2.1: sodium hydrogencarbonate / dichloromethane

2.2: 12 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; In ethanol; dichloromethane;

DOI:10.1002/chem.201203097

upstream raw materials:

tyrosamine

N,N'-bis(2-hydroxyethyl)-2,6-dibromonaphthalene-1,4,5,8-tetracarboxylic acid 1,8:4,5-diimide

2,6-dibromo-1,4,5,8-naphthalenetetracarboxylic acid dianhydride

Downstream raw materials:

N,N'-bis(2-hydroxyethyl)-2-bromo-6-(2-(3-(trimethylamino)methyl-4-hydroxyphenyl)ethylamino)-1,4,5,8-naphthalenetetracarboxylic acid 1,8:4,5-diimide iodide