Technology Process of methyl (+/-)-1-(2-aminophenyl)-8-ethyl-3-formyl-5,6,7,8-tetrahydroindolizin-8-acetate
There total 7 articles about methyl (+/-)-1-(2-aminophenyl)-8-ethyl-3-formyl-5,6,7,8-tetrahydroindolizin-8-acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; toluene;
at 80 ℃;
for 2h;
DOI:10.1039/b209992f
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 87 percent / Et3N; (2-pyridine N-oxide)disulfide; Bu3P / 16 h / 18 °C
2.1: diethyl ether / 1 h / 18 °C
2.2: 95 percent / aq. KHSO4 / diethyl ether / 0.1 h / -40 °C
3.1: 77 percent / NaH / 48 h / 18 °C
4.1: 83 percent / AlCl3 / diethyl ether / 5 h / 18 °C
5.1: 95 percent / POCl3 / diethyl ether / 3.5 h / 0 - 18 °C
6.1: 75 percent / I2; silver trifluoroacetate / CHCl3 / 4 h / 18 °C
7.1: 76 percent / aq. Na2CO3 / Pd(PPh3)4 / methanol; toluene / 2 h / 80 °C
With
aluminium trichloride; tributylphosphine; (2-pyridine N-oxide)disulfide; iodine; silver trifluoroacetate; sodium hydride; sodium carbonate; triethylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; diethyl ether; chloroform; toluene;
3.1: Wadsworth-Emmons reaction / 4.1: Michael addition / 5.1: Vilsmeier-Haack formylation / 7.1: Suzuki-Miyuara cross-coupling;
DOI:10.1039/b209992f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diethyl ether / 1 h / 18 °C
1.2: 95 percent / aq. KHSO4 / diethyl ether / 0.1 h / -40 °C
2.1: 77 percent / NaH / 48 h / 18 °C
3.1: 83 percent / AlCl3 / diethyl ether / 5 h / 18 °C
4.1: 95 percent / POCl3 / diethyl ether / 3.5 h / 0 - 18 °C
5.1: 75 percent / I2; silver trifluoroacetate / CHCl3 / 4 h / 18 °C
6.1: 76 percent / aq. Na2CO3 / Pd(PPh3)4 / methanol; toluene / 2 h / 80 °C
With
aluminium trichloride; iodine; silver trifluoroacetate; sodium hydride; sodium carbonate; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; diethyl ether; chloroform; toluene;
2.1: Wadsworth-Emmons reaction / 3.1: Michael addition / 4.1: Vilsmeier-Haack formylation / 6.1: Suzuki-Miyuara cross-coupling;
DOI:10.1039/b209992f
