4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile

Base Information

• Chemical Name: 4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile
• CAS No.: 1151549-82-4
• Molecular Formula: C₂₄H₁₅NO
• Molecular Weight: 333.389
• Mol file: 1151549-82-4.mol

Synonyms:4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile

Chemical Property of 4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile

There total 13 articles about 4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-bromobenzenecarbonitrile (623-00-7) + 1-ethynyl-3-(4-methoxyphenylethynyl)benzene (1351165-69-9) → 4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile (1151549-82-4)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; In toluene; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0030-1261223

Reference yield: 18.0%

4-cyanophenylacetylene (3032-92-6) + 1-(4-methoxyphenyl)-2-(3-bromophenyl)acetylene → 4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile (1151549-82-4)

Guidance literature:

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine; In tetrahydrofuran; toluene; Inert atmosphere;

DOI:10.1021/jo900494j

Reference yield:

4-iodobenzonitrile (3058-39-7) + 1-ethynyl-3-(4-methoxyphenylethynyl)benzene (1351165-69-9) → 4-[2-[3-[2-(4-methoxyphenyl)ethynyl]phenyl]ethynyl]benzonitrile (1151549-82-4)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; In tetrahydrofuran; toluene; at 60 ℃; for 15h; Inert atmosphere;

DOI:10.3184/174751918X15269925671284

upstream raw materials:

4-cyanophenylacetylene

((3-ethynylphenyl)ethynyl)diphenylphosphine oxide

3-(4-methoxyphenylethynyl)phenylethynyldiphenylphosphine oxide

4-bromobenzenecarbonitrile