(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

Base Information

Chemical Name:(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate
CAS No.:1428259-48-6
Molecular Formula:C₁₉H₁₈ClF₃N₂O₃
Molecular Weight:414.812
Hs Code.:

Synonyms:(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

Suppliers and Price of (2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

There total 6 articles about (2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 99333-34-3
N-(2,2,2-trifluoroethylidene)-4-methoxyaniline

: 1428259-48-6
(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

Guidance literature:: With tetrakis(acetonitrile)copper(I)tetrafluoroborate; C₂₅H₂₅FeOP; triethylamine; In diethyl ether; at -20 ℃; Temperature; Time; Solvent; enantioselective reaction; Catalytic behavior; Inert atmosphere;
DOI:10.1039/c3cc43025a

Reference yield: 68.0%

: 1428259-85-1
(2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate

: 104-88-1
4-chlorobenzaldehyde

: 1428259-48-6
(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1021/acs.joc.8b01743

Reference yield:

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 99333-34-3
N-(2,2,2-trifluoroethylidene)-4-methoxyaniline

: 1428259-48-6
(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

: 1428259-87-3
(2S,4S,5S)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

Guidance literature:: With C₂₅H₂₅FeOP; silver(I) acetate; triethylamine; In dichloromethane; at 20 ℃; for 0.166667h; Reagent/catalyst; Overall yield = 90 %; enantioselective reaction;
DOI:10.1039/c3cc43025a