(2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate

Base Information

Chemical Name:(2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate
CAS No.:1428259-85-1
Molecular Formula:C₁₂H₁₅F₃N₂O₃
Molecular Weight:292.258
Hs Code.:

Synonyms:(2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate

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Chemical Property of (2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate

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Technology Process of (2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate

There total 4 articles about (2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1428259-48-6
(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)imidazolidine-4-carboxylate

: 1428259-85-1
(2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 5h;
DOI:10.1039/c3cc43025a

Reference yield:

: 81167-39-7
methyl N-(diphenylmethylene)glycinate

: 99333-34-3
N-(2,2,2-trifluoroethylidene)-4-methoxyaniline

: 1428259-85-1
(2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate

: C₁₂H₁₅F₃N₂O₃

Guidance literature:: methyl N-(diphenylmethylene)glycinate; N-(2,2,2-trifluoroethylidene)-4-methoxyaniline; With tetrakis(acetonitrile)copper(I)tetrafluoroborate; C₂₅H₂₅FeOP; triethylamine; In diethyl ether; at -20 - 20 ℃; for 5h; Inert atmosphere;

With toluene-4-sulfonic acid; In methanol; at 20 ℃; Solvent; Overall yield = 75 %;
DOI:10.1021/acs.joc.8b01743

Reference yield:

: 99333-34-3
N-(2,2,2-trifluoroethylidene)-4-methoxyaniline

: 1428259-85-1
(2R,3R)-methyl 2 -amino-4,4,4-trifluoro-3-((4-methoxyphenyl)amino)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; tetrakis(acetonitrile)copper(I)tetrafluoroborate; C₂₅H₂₅FeOP / diethyl ether / -20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / methanol / 5 h / 20 °C

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; C₂₅H₂₅FeOP; toluene-4-sulfonic acid; triethylamine; In methanol; diethyl ether;
DOI:10.1039/c3cc43025a