3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde

Base Information

• Chemical Name: 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde
• CAS No.: 180283-48-1
• Molecular Formula: C₁₄H₁₅NO₃S
• Molecular Weight: 277.344
• Mol file: 180283-48-1.mol

Synonyms:3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde

Chemical Property of 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde

There total 1 articles about 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dimethylpyrrole-2-carboxaldehyde (19713-89-4) + p-toluenesulfonyl chloride (98-59-9) → 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde (180283-48-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, RT, 1 h, 2.) THF, 16 h;

DOI:10.1055/s-1996-4308

Reference yield: 95.0%

3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde (180283-48-1) → [3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrol-2-yl]-methanol (180283-67-4)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1055/s-1996-4308

Reference yield:

3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde (180283-48-1) → 2,5-bis(3,4-dimethyl-1-tosyl-1H-pyrrol-2-ylmethyl)-3-ethyl-4-methyl-1H-pyrrole

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / LiBH₄ / tetrahydrofuran / 2 h / 20 °C

2: 20 percent / 10percent aq. HCl / dioxane / 4 h / Ambient temperature

With hydrogenchloride; lithium borohydride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1055/s-1996-4308

upstream raw materials:

3,4-dimethylpyrrole-2-carboxaldehyde

p-toluenesulfonyl chloride

Downstream raw materials:

[3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrol-2-yl]-methanol