(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

Base Information

Chemical Name:(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester
CAS No.:190446-43-6
Molecular Formula:C₂₉H₃₅N₅O₈
Molecular Weight:581.626
Hs Code.:

(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

Synonyms:(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

Suppliers and Price of (S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

There total 6 articles about (S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75760-11-1
(S)-methyl 3-amino-2-(((benzyloxy)carbonyl)amino)propanoate

: 170726-53-1
(R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetic acid

: 190446-43-6
(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jm960799i

Reference yield:

: 52707-54-7,52707-59-2,64847-77-4
4-cyanobenzaldehyde oxime

: 190446-43-6
(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 34 percent / aq. NaOCl / tetrahydrofuran / Ambient temperature

2: 73 percent / HCl / 24 h / Ambient temperature

3: NH₃ / methanol / 14 h / Ambient temperature

4: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

5: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

6: 89 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafkuoroborate, Et₃N / dimethylformamide / 16 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; sodium hypochlorite; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i

Reference yield:

: 170229-13-7
[3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid

: 190446-43-6
(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / HCl / 24 h / Ambient temperature

2: NH₃ / methanol / 14 h / Ambient temperature

3: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

4: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

5: 89 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafkuoroborate, Et₃N / dimethylformamide / 16 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i