methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate

Base Information

Chemical Name:methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate
CAS No.:1417456-48-4
Molecular Formula:C₁₄H₁₅ClN₂O₃S
Molecular Weight:326.804
Hs Code.:

Synonyms:methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate

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Chemical Property of methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate

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Technology Process of methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate

There total 3 articles about methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 53377-25-6
3-(4-chlorophenyl)-2-thioxotetrahydropyrimidin-4(1H)-one

: 1417456-48-4
methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1055/S-0032-1317133

Reference yield:

: 3744-12-5
1-(2-carboxyethyl) 3-p-chlorophenylthiouree

: 1417456-48-4
methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole / acetonitrile / 0.17 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With potassium carbonate; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/S-0032-1317133

Reference yield:

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1417456-48-4
methyl 3-(3-(4-chlorophenyl)-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 1.6 h / 20 °C

2: 1,1'-carbonyldiimidazole / acetonitrile / 0.17 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/S-0032-1317133