3744-12-5Relevant academic research and scientific papers
A facile synthesis and chemoselective reactions of dihydrothiouracils
Kumar, Varan,Khatik, Gopal L.,Pal, Anang,Praneeth, Mohan R.,Bhattarai, Sanjay,Nair, Vipin A.
supporting information, p. 2357 - 2362 (2013/07/19)
A highly efficient procedure was devised for the synthesis of 3-(3-arylthioureido)propanoic/butanoic acid and its cyclization to (3-ary1/3-ary1-6-methyl)-2-thioxotetrahydropyrimidin-4(1H)-one derivatives. Carbonyl diimidazole proved to be a very effective coupling reagent for the cyclization. Studies carried out to examine the ambident nature of the thioamide moiety towards substitution reactions demonstrated the preference for alkylation at sulfur, and acylation and 1,4-addition at nitrogen. Georg Thieme Verlag Stuttgart · New York.
Formation of dihydrouracils via cyclization of N-substituted 3-thioureidopropanoic acids and facile desulfurization
Delpiccolo, Carina M.L.,Albericio, Fernando,Schiksnis, Robert A.,Michelotti, Enrique L.
, p. 8949 - 8953 (2008/02/10)
Cyclization of N-3 substituted 3-thioureidopropanoic acids in isobutyric anhydride at high temperature resulted in the unexpected formation of N-3,N-1-substituted dihydrouracils, as confirmed by thorough spectroscopic characterization. A mechanism based on the identification of intermediates observed at lower reaction temperatures is proposed.
Synthese, activite antiparasitaire et antifongique de thioureines a motif aminoacide
Caujolle, R,Payard, M,Loiseau, PR,Amarouch, H,Linas, MD,et al.
, p. 723 - 727 (2007/10/02)
Sixteen compounds, close to aryl or aralkylthioureines, with a β-alanine or γ-aminobutyric acid chain, were synthesized for in vitro screening towards 3 types of nematodes, 8 classes of opportunist germs and 34 classes of yeasts.Their anthelmintic activit
