Technology Process of octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester
There total 13 articles about octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
jones' reagent;
In
acetone;
for 3.5h;
Ambient temperature;
DOI:10.1021/ja00260a020
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 71 percent / pyridine, triphenylphosphine, carbon tetrabromide / CH2Cl2 / 2.5 h
2: 19 percent / tert-butyllithium / diethyl ether
3: 77 percent / 1N HCl / tetrahydrofuran / Ambient temperature
4: 86 percent / pyridine / CHCl3 / 0 deg C up to RT
5: 60 percent / NaBH4 / ethanol; CHCl3 / 0.5 h / 32 °C
6: 87 percent / pyridine / Ambient temperature
7: 60 percent / Jones' reagent / acetone / 3.5 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium tetrahydroborate; jones' reagent; carbon tetrabromide; tert.-butyl lithium; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/ja00260a020
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 72 percent / 4 h / Heating
2: 82 percent / LiAlH4
3: 71 percent / pyridine, triphenylphosphine, carbon tetrabromide / CH2Cl2 / 2.5 h
4: 19 percent / tert-butyllithium / diethyl ether
5: 77 percent / 1N HCl / tetrahydrofuran / Ambient temperature
6: 86 percent / pyridine / CHCl3 / 0 deg C up to RT
7: 60 percent / NaBH4 / ethanol; CHCl3 / 0.5 h / 32 °C
8: 87 percent / pyridine / Ambient temperature
9: 60 percent / Jones' reagent / acetone / 3.5 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; jones' reagent; carbon tetrabromide; tert.-butyl lithium; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/ja00260a020