octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester

Base Information

Chemical Name:octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester
CAS No.:111935-10-5
Molecular Formula:C₅₂H₈₅F₂O₇P
Molecular Weight:891.213
Hs Code.:

octadecanoic acid, 5,5-difluoro-4-oxo-2-<<<diphenoxyphosphinyl>oxy>methyl>heneicosanyl ester

Synonyms:octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester

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Chemical Property of octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester

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Technology Process of octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester

There total 13 articles about octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: octadecanoic acid, (R*,R*)- and (R*,S*)-5,5-difluoro-4-hydroxy-2-<<oxy>methyl>heneicosanyl ester

: 111935-10-5
octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester

Guidance literature:: With jones' reagent; In acetone; for 3.5h; Ambient temperature;
DOI:10.1021/ja00260a020

Reference yield:

: 4728-12-5
2,2-dimethyl-5-hydroxymethyl-1,3-dioxane

: 111935-10-5
octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 71 percent / pyridine, triphenylphosphine, carbon tetrabromide / CH₂Cl₂ / 2.5 h

2: 19 percent / tert-butyllithium / diethyl ether

3: 77 percent / 1N HCl / tetrahydrofuran / Ambient temperature

4: 86 percent / pyridine / CHCl₃ / 0 deg C up to RT

5: 60 percent / NaBH₄ / ethanol; CHCl₃ / 0.5 h / 32 °C

6: 87 percent / pyridine / Ambient temperature

7: 60 percent / Jones' reagent / acetone / 3.5 h / Ambient temperature

With pyridine; hydrogenchloride; sodium tetrahydroborate; jones' reagent; carbon tetrabromide; tert.-butyl lithium; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/ja00260a020

Reference yield:

: 51335-75-2
2,2-Dimethyl-1,3-dioxacyclohexane-5,5-dicarboxylic acid,diethyl ester

: 111935-10-5
octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 72 percent / 4 h / Heating

2: 82 percent / LiAlH₄

3: 71 percent / pyridine, triphenylphosphine, carbon tetrabromide / CH₂Cl₂ / 2.5 h

4: 19 percent / tert-butyllithium / diethyl ether

5: 77 percent / 1N HCl / tetrahydrofuran / Ambient temperature

6: 86 percent / pyridine / CHCl₃ / 0 deg C up to RT

7: 60 percent / NaBH₄ / ethanol; CHCl₃ / 0.5 h / 32 °C

8: 87 percent / pyridine / Ambient temperature

9: 60 percent / Jones' reagent / acetone / 3.5 h / Ambient temperature

With pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; jones' reagent; carbon tetrabromide; tert.-butyl lithium; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/ja00260a020