N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide

Base Information

Chemical Name:N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide
CAS No.:1401094-69-6
Molecular Formula:C₁₅H₁₉F₃N₂O₅S
Molecular Weight:396.387
Hs Code.:

N<sup>2</sup>-[(benzyloxy)carbonyl]-N<sup>1</sup>-[(trifluoromethyl)sulfonyl]-(L)-leucinamide

Synonyms:N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide

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Chemical Property of N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide

Chemical Property:

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Technology Process of N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide

There total 3 articles about N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 2018-66-8
Z-Leu-OH

: 421-85-2
Trifluoromethanesulfonamide

: 1401094-69-6
N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide

Guidance literature:: With benzotriazol-1-ol; 1,2-dichloro-ethane; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1039/c3dt33039g

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 1401094-69-6
N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 2.25 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxybenzotriazol-hydrate / dichloromethane / 72 h / 0 - 20 °C

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dichloromethane; water;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1401094-69-6
N²-[(benzyloxy)carbonyl]-N¹-[(trifluoromethyl)sulfonyl]-(L)-leucinamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 2.25 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxybenzotriazol-hydrate / dichloromethane / 72 h / 0 - 20 °C

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dichloromethane; water;