3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide

Base Information

• Chemical Name: 3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide
• CAS No.: 1166859-75-1
• Molecular Formula: C₁₄H₁₃NO₃S
• Molecular Weight: 275.328
• Mol file: 1166859-75-1.mol

Synonyms:3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide

Chemical Property of 3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide

There total 1 articles about 3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(3-hydroxymethyl-phenyl)-1,2-benzothiazole 1,1-dioxide (1166859-57-9) → 3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide (1166859-75-1)

Guidance literature:

With C₄₀H₄₄IrN₆⁽¹⁺⁾*F₆P^(1-); ammonium formate; In water; N,N-dimethyl-formamide; at 60 ℃; for 4h; enantioselective reaction;

DOI:10.1039/c7cc04691j

Reference yield: 97.0%

3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide (1166859-75-1) + methyl iodide (74-88-4) → N-methyl-3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide (1166859-79-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jo900790k

upstream raw materials:

3-(3-hydroxymethyl-phenyl)-1,2-benzothiazole 1,1-dioxide

Downstream raw materials:

N-methyl-3-(3-hydroxymethyl-phenyl)-1,2-benzisothiazoline 1,1-dioxide