10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

Base Information

Chemical Name:10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one
CAS No.:1416000-28-6
Molecular Formula:C₂₄H₁₂F₆N₄O
Molecular Weight:486.376
Hs Code.:

Synonyms:10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

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Chemical Property of 10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

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Technology Process of 10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

There total 10 articles about 10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.5%

: 1084953-47-8
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine

: 1416000-57-1
2-chloro-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

: 1416000-28-6
10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 90 ℃; for 16h; Cooling; Inert atmosphere;

Reference yield:

: 127094-57-9
4,6-dichloro-(1,5)-naphthyridine-3-carboxylic acid ethyl ester

: 1416000-28-6
10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tert-butyl alcohol / 3 h / Reflux

2: sodium tetrahydroborate; ethanol / 24 h / 20 °C

3: manganese(IV) oxide / dichloromethane / 8 h / 20 °C

4: N,N-dimethyl acetamide / 0.67 h / 160 °C / Microwave irradiation

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 16 h / 90 °C / Cooling; Inert atmosphere

With manganese(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; sodium carbonate; potassium carbonate; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; tert-butyl alcohol;

Reference yield:

: 1416000-54-8
6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

: 1416000-28-6
10-(3-(trifluoromethyl)phenyl)-2-(5-(trifluoromethyl)pyridin-3-yl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tert-butyl alcohol / 36 h / 160 °C / Sealed tube

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 16 h / 90 °C / Cooling; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In 1,4-dioxane; tert-butyl alcohol;