butyl 4-[(2-{(2R)-2-[(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-(3-methylphenyl)but-1-enyl]-5-thioxopyrrolidin-1-yl}ethyl)sulfanyl]butanoate

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Chemical Name:butyl 4-[(2-{(2R)-2-[(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-(3-methylphenyl)but-1-enyl]-5-thioxopyrrolidin-1-yl}ethyl)sulfanyl]butanoate
CAS No.:1357177-80-0
Molecular Formula:C₃₁H₅₁NO₃S₂Si
Molecular Weight:577.968
Hs Code.:

Synonyms:butyl 4-[(2-{(2R)-2-[(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-(3-methylphenyl)but-1-enyl]-5-thioxopyrrolidin-1-yl}ethyl)sulfanyl]butanoate

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Chemical Property of butyl 4-[(2-{(2R)-2-[(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-(3-methylphenyl)but-1-enyl]-5-thioxopyrrolidin-1-yl}ethyl)sulfanyl]butanoate

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Technology Process of butyl 4-[(2-{(2R)-2-[(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-(3-methylphenyl)but-1-enyl]-5-thioxopyrrolidin-1-yl}ethyl)sulfanyl]butanoate

There total 2 articles about butyl 4-[(2-{(2R)-2-[(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-(3-methylphenyl)but-1-enyl]-5-thioxopyrrolidin-1-yl}ethyl)sulfanyl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (15α,13E)-9-oxo-15-t-butyldimethylsilyloxy-16-(3-methylphenyl)-17,18,19,20-tetranor-5-thia-8-azaprost-13-enoic acid butyl ester

: 1357177-80-0
butyl 4-[(2-{(2R)-2-[(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-(3-methylphenyl)but-1-enyl]-5-thioxopyrrolidin-1-yl}ethyl)sulfanyl]butanoate

Guidance literature:: With Lawessons reagent; In toluene; at 50 ℃; for 1h;

Reference yield:

: 1357177-79-7
C₂₅H₃₇NO₄S

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1357177-80-0
butyl 4-[(2-{(2R)-2-[(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-(3-methylphenyl)but-1-enyl]-5-thioxopyrrolidin-1-yl}ethyl)sulfanyl]butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

2: Lawessons reagent / toluene / 1 h / 50 °C / Inert atmosphere

With Lawessons reagent; 1H-imidazole; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.12.009